Aging & Sarcopenia

Healthy aging starts with healthy muscles.


Healthy muscles are essential for maintaining mobility, physical function and independence throughout life. As muscle mass and strength naturally decline with age, preserving muscle health has become a key priority for healthy aging. Growing scientific evidence also highlights the important role of nutrition and the gut microbiome in supporting muscle function across the aging journey.


TWK10® is a clinically studied Lactiplantibacillus plantarum strain that supports muscle health through the gut–muscle axis. Supported by an extensive body of clinical and mechanistic research, TWK10® offers a microbiome-based approach to maintaining muscle strength, mobility and physical performance during aging.


Why Muscle Health Matters

Sarcopenia is a progressive skeletal muscle disorder characterized by the age-related loss of muscle mass and strength. It is associated with an increased risk of falls, frailty, reduced physical function and loss of independence. As global populations continue to age, maintaining muscle health is becoming an increasingly important focus of healthy aging strategies.


Age-related muscle loss: a growing global concern

Age-related muscle loss is a gradual process that often begins in midlife and accelerates in later years. Because these changes occur progressively, they may remain unnoticed until mobility, strength and physical independence are affected. Understanding this trajectory highlights the importance of early nutritional strategies to help maintain muscle health throughout the aging process.

 

Three challenges in healthy aging

• Muscle loss & reduced mobility : declining strength limits movement and independence.

• Low energy & slow recovery : fatigue increases and recovery becomes prolonged.

• Poor nutrient utilization : nutrition intake becomes less efficiently used.


The gut–muscle axis: how TWK10® works

The gut–muscle axis provides the biological foundation for TWK10®'s benefits. By supporting a healthy gut microbiome and increasing SCFA production, TWK10® promotes efficient nutrient utilization, energy metabolism, and glycogen synthesis. Together, these mechanisms contribute to improved muscle function, physical performance, and healthy aging.


Flexible Formats for Every Needs

TWK10® is available in both probiotic and postbiotic forms and can be formulated into a variety of delivery formats, enabling flexible product development for diverse healthy-aging applications and consumer preferences.



 


From concept to solution, we support your innovation

Our CDMO expertise ensures the highest quality, stability and performance in every format.

References

  1. Lee M-C, Tu Y-T, et al. TWK10 improves muscle mass and functional performance in frail older adults: a randomized, double-blind clinical trial. Microorganisms. 2021;9(7):1466.
  2. Lee C-C, et al. TWK10 attenuates aging-associated muscle weakness, bone loss and cognitive impairment in mice. Front Nutr. 2021;8:708096.
  3. Grimby, G., & Saltin, B. (1983). Landmark study on age-related muscle changes.
  4. Kim, T. N., & Choi, K. M. (2013). Review of sarcopenia definition and epidemiology.
  5. Mitchell, W. K., et al. (2012). Review of age-related declines in muscle mass and strength.
  6. Petermann-Rocha, F., et al. (2022). Global meta-analysis of sarcopenia prevalence.
  7. Jang, J., et al. (2025). Review of nutritional strategies for sarcopenia.