The Science and Recognition Behind SynForU™-ReMain
Backed by research, patents, and international recognition
SynForU™-ReMain is supported by four peer-reviewed publications, spanning human clinical, preclinical, and cross-species research. Its intellectual property is protected by invention patents in Taiwan and the United States, and the formula has received multiple international invention awards.
Explore the research and recognition below, with links to the primary sources.
Human clinical study
Chan W-N, Ho D-R, Huang Y-C, Lin J-H, Liu Y-L, Chen M-J, Chen C-S. A Pilot Study of Nephrogenic Probiotics to Further Improve an Already Stabilized Graft Function After Kidney Transplantation. Transplant Proc. 2023;55(9):2090-2094. DOI 10.1016/j.transproceed.2023.08.011
Mechanistic / preclinical study
Huang H, Li K, Lee Y-J, Chen M-J. Preventive Effects of a Lactobacillus Mixture against Chronic Kidney Disease Progression through Enhancement of Beneficial Bacteria and Downregulation of Gut-Derived Uremic Toxins. J Agric Food Chem. 2021;69(26):7353-7366. DOI 10.1021/acs.jafc.1c01547
Cross-species evidence
- Tsai C-W, Huang H-W, Lee Y-J, Chen M-J. Investigating the Efficacy of a Kidney-Protective Lactobacillus Mixture-Containing Pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism. Animals. 2024;14(4):630. DOI 10.3390/ani14040630
- Huang H-W, Kuo T-C, Lee Y-J, Chen M-J. Multi-omics analysis reveals the efficacy of two probiotic strains in managing feline chronic kidney disease through gut microbiome and host metabolome. Front Vet Sci. 2025;12:1590388. DOI 10.3389/fvets.2025.1590388
Patents
SynForU-ReMain’s two-strain probiotic composition and its use for kidney health are protected by granted invention patents in Taiwan and the United States:
- TW I770811 (Probiotics, Composition and Use Thereof)
- US 12,220,436 B2 (Probiotic Compositions and Uses Thereof)
International recognition
All awards recognize SynForU™-ReMain’s probiotic innovation in advancing gut–kidney axis research and kidney health.
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